Protein Phosphatase 2A (PP2A) Regulates Low Density Lipoprotein Uptake through Regulating Sterol Response Element-binding Protein-2 (SREBP-2) DNA Binding

[Sterol regulatory element binding protein (SREBP)].

Low-density lipoprotein upregulates low-density lipoprotein receptor-related protein expression in vascular smooth muscle cells: possible involvement of sterol regulatory element binding protein-2-dependent mechanism.

BACKGROUND Low-density lipoprotein (LDL) receptor-related protein (LRP) is highly expressed in vascular smooth muscle cells (VSMCs) of both normal and atherosclerotic lesions. However, little is known about LRP regulation in the vascular wall. METHODS AND RESULTS We analyzed the regulation of LRP expression in vitro in human VSMCs cultured with native LDL (nLDL) or aggregated LDL (agLDL) by s...

Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2).

High affinity uptake of serum-derived low density lipoprotein (LDL) cholesterol is accomplished through the LDL receptor in the liver. In mammals, thyroid hormone depletion leads to decreased LDL receptor expression and elevated serum cholesterol. The clinical association in humans has been known since the 1920s; however, a molecular explanation has been lacking. LDL receptor levels are subject...

Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs.

In the present study, we aimed to decipher the mechanisms involved in the transcriptional effect of insulin on the SREBP-1c specific promoter of the human srebf-1 gene. Using luciferase reporter gene constructs in HEK-293 cells (human embryonic kidney cells), we demonstrated that the full effect of insulin requires the presence of SREs (sterol response elements) in the proximal region of the pr...

Binding Protein-2-Dependent Mechanism Expression in Vascular Smooth Muscle Cells : Possible Involvement of Sterol Regulatory Low-Density Lipoprotein Upregulates Low-Density Lipoprotein Receptor-Related Protein

Vicenta Llorente-Cortés, Marta Otero-Viñas, Sonia Sánchez, Cristina Rodríguez and Lina Element Binding Protein-2-Dependent Mechanism Expression in Vascular Smooth Muscle Cells : Possible Involvement of Sterol Regulatory Low-Density Lipoprotein Upregulates Low-Density Lipoprotein Receptor-Related Protein Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2002 American Heart Association, I...